Using Urokinase and Plasma to Unblock Catheters
Author Information
Author(s): Georg Seifert, Hanno Riess, Karl Seeger, Günter Henze, Anja Borgmann
Primary Institution: Charité – Universitätsmedizin Berlin, Germany
Hypothesis
Can the combination of urokinase and autologous plasma effectively treat occluded central venous ports?
Conclusion
Instillation of r-UK and autologous plasma is a safe and effective method for management of CVP occlusion.
Supporting Evidence
- All patients were successfully treated with thrombolytic therapy using intraluminal instillation of r-UK and autologous plasma.
- No patient experienced adverse effects during or after instillation.
- The entire management procedure was easy to perform and well tolerated.
Takeaway
Doctors used a special mixture of a medicine and the patient's own blood to help unblock catheters that were stuck.
Methodology
Five patients with occluded central venous ports were treated using a combination of autologous plasma and urokinase.
Limitations
In one case, the treatment failed due to a silicon particle occluding the catheter.
Participant Demographics
[{"initials":"NK","age":6,"diagnosis":"Hemophilia","therapy":"Factor VIII"},{"initials":"AH","age":3,"diagnosis":"Hemophilia","therapy":"Factor VIII"},{"initials":"HR","age":67,"diagnosis":"Hepatocellular Carcinoma","therapy":"Fluorouracil, Folic Acid"},{"initials":"MA","age":51,"diagnosis":"Colon Carcinoma","therapy":"Fluorouracil, Folic Acid"},{"initials":"BH","age":53,"diagnosis":"Mammary Carcinoma","therapy":"Fluorouracil, Doxorubicin"}]
Digital Object Identifier (DOI)
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