Clinical Course of Hyperprolactinemia in Children and Adolescents
Author Information
Author(s): Eren Erdal, Yapıcı Şenay, Çakır Esra Deniz Papatya, Ceylan Latife Aytekin, Sağlam Halil, Tarım Ömer
Primary Institution: Uludağ University, Faculty of Medicine, Bursa, Turkey
Hypothesis
The study aimed to evaluate the clinical course and outcome of hyperprolactinemia in pediatric patients.
Conclusion
Hyperprolactinemia should be considered as a probable diagnosis in children with symptoms suggestive of pituitary-gonadal axis suppression, and medical therapy is effective for microadenomas.
Supporting Evidence
- Menstrual problems, galactorrhea, and headache were the most common symptoms.
- Hyperprolactinemia was due to microadenoma in 10 patients, macroadenoma in 7, and drug-induced in 4.
- Bromocriptine and cabergoline were equally effective in lowering serum prolactin levels.
- Surgical treatment for macroprolactinoma was not curative, requiring postoperative medical therapy.
Takeaway
This study looked at kids with high prolactin levels and found that some had tumors, while others had issues from medications. Treating them with medicine worked well for most.
Methodology
The study was retrospective, analyzing records of 21 patients with hyperprolactinemia from a tertiary hospital.
Limitations
The study is limited by its retrospective design and small sample size.
Participant Demographics
The study included 17 girls (81%) and 4 boys (19%) with a mean age at diagnosis not specified.
Statistical Information
P-Value
p=0.024
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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