Viruses as co-factors for the initiation or exacerbation of lung fibrosis
2008
Viruses and Lung Fibrosis
publication
Evidence: moderate
Author Information
Author(s): Vannella Kevin M, Moore Bethany B
Primary Institution: University of Michigan Medical School
Hypothesis
Viral infections may augment fibrotic responses in idiopathic pulmonary fibrosis (IPF).
Conclusion
The evidence suggests that viral infections should be considered as potential initiators or exacerbating agents in some cases of IPF.
Supporting Evidence
- Viral infections may disrupt normal healing responses in the lungs.
- Gammaherpesvirus infections have been linked to fibrotic progression in animal models.
- Studies show that Epstein-Barr virus is present in the lungs of IPF patients more than in controls.
Takeaway
Some viruses might make lung scarring worse in people with a disease called idiopathic pulmonary fibrosis.
Methodology
This review summarizes clinical and experimental observations linking viral infections to lung fibrosis.
Limitations
The studies reviewed do not prove causality between viral infections and IPF.
Digital Object Identifier (DOI)
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