Impact of P. gingivalis Infection on Vascular Reactivity in Mice
Author Information
Author(s): Raquel B Pereira, Elisardo C Vasquez, Ivanita Stefanon, Silvana S Meyrelles
Primary Institution: Federal University of Espirito Santo
Hypothesis
Does oral P. gingivalis infection alter vascular responsiveness in mice with spontaneous atherosclerosis?
Conclusion
Oral P. gingivalis infection increases vasoconstrictor response to phenylephrine in both healthy and atherosclerotic mice.
Supporting Evidence
- P. gingivalis infection significantly enhanced vasoconstriction to phenylephrine in both healthy and atherosclerotic mice.
- Alveolar bone resorption was confirmed in all infected mice.
- Non-infected ApoE mice were hyperreactive to phenylephrine compared to non-infected healthy mice.
Takeaway
This study shows that a bacteria from the mouth can make blood vessels react more strongly, which might be bad for heart health.
Methodology
Mice were infected with P. gingivalis and vascular responses were measured using various agonists.
Limitations
Only one periodontal pathogen was studied, and the effects of multiple pathogens were not assessed.
Participant Demographics
Adult male C57 and ApoE mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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