Molecular Profiling of Endometrial Tissue in Uterus Didelphys
Author Information
Author(s): Sola-Leyva Alberto, Romero Bárbara, Canha-Gouveia Analuce, Pérez-Prieto Inmaculada, Molina Nerea M., Vargas Eva, Mozas-Moreno Juan, Chamorro Clara, Saare Merli, Salumets Andres, Altmäe Signe
Primary Institution: Karolinska University Hospital
Hypothesis
How does the physical separation in uterus didelphys affect endometrial microbiome and inflammation?
Conclusion
The study found significant microbiome variations between the two uteri in uterus didelphys, despite similar endometrial receptivity patterns.
Supporting Evidence
- Endometrial receptivity analyses showed similar receptive states in both uteri.
- Differential markers of chronic endometritis were observed, with the right uterus showing a higher prevalence.
- Significant differences in microbiome composition were found, particularly in the right uterus.
- The right uterus had a less favorable microenvironment with lower lactobacilli levels.
- Both uteri shared a similar metabolomic profile but exhibited variations in specific metabolites.
Takeaway
Women with a double uterus can have different bacteria and inflammation in each side, which might affect their chances of getting pregnant.
Methodology
Endometrial samples were collected from both uterine cavities during the mid-secretory phase and analyzed for microbiome, metabolome, and immunological features.
Potential Biases
The study's findings may be influenced by the patient's unique medical history and the presence of multiple complicating factors.
Limitations
Results are based on a single case and may not be generalizable; potential contamination in microbiome analysis could affect findings.
Participant Demographics
A 36-year-old woman with primary infertility and a BMI of 31.5 kg/m².
Digital Object Identifier (DOI)
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