Mixed Cryoglobulinemia in Chikungunya Infection
Author Information
Author(s): Oliver Manuela, Grandadam Marc, Marimoutou Catherine, Rogier Christophe, Botelho-Nevers Elisabeth, Tolou Hugues, Moalic Jean-Luc, Kraemer Philippe, Morillon Marc, Morand Jean-Jacques, Jeandel Pierre, Parola Philippe, Simon Fabrice
Primary Institution: Hôpital d'Instruction des Armées Laveran, Marseille, France
Hypothesis
Cryoglobulins may play a role in the chronic stage of Chikungunya virus infection.
Conclusion
The prevalence of mixed cryoglobulinemia was high in Chikungunya-infected travelers with long-lasting symptoms, but no significant association with clinical manifestations was found.
Supporting Evidence
- 94% of CHIKV-infected patients had cryoglobulinemia at least once during follow-up.
- Over 90% of patients experienced arthralgias alongside cryoglobulinemia.
- Cryoglobulin levels decreased over time as patients recovered.
Takeaway
Chikungunya can cause long-lasting joint pain, and many people with this infection also have a condition called cryoglobulinemia, which can affect their blood tests.
Methodology
Patients with suspected Chikungunya infection were recorded, and demographic, clinical, and laboratory findings were collected over follow-up.
Potential Biases
Potential bias due to the high sensitivity of the cryoglobulinemia detection method used.
Limitations
The study did not include seronegative patients for ethical reasons, and the follow-up was limited to symptomatic patients.
Participant Demographics
Median age of participants was 54 years, with a sex ratio of 1.04 (M/F).
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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