pAKT and Radiation Resistance in Cervical Cancer
Author Information
Author(s): Kim T-J, Lee J-W, Song S Y, Choi J-J, Choi C H, Kim B-G, Lee J-H, Bae D-S
Primary Institution: Samsung Medical Center, Sungkyunkwan University School of Medicine
Hypothesis
Is increased pAKT expression associated with radiation resistance in cervical cancer?
Conclusion
Increased pAKT expression is linked to radiation resistance and may serve as a prognostic marker in cervical cancer.
Supporting Evidence
- Patients with pAKT-positive expression had a mean progression-free survival of 44 months.
- Patients with pAKT-negative staining had a mean progression-free survival of 86 months.
- The study found a significant association between pAKT expression and local recurrence.
Takeaway
This study found that higher levels of a protein called pAKT in cervical cancer patients can make them less responsive to radiation treatment.
Methodology
The study involved a retrospective review of 27 patients' records and immunohistochemical evaluation of pAKT expression in tissue samples.
Potential Biases
Selection bias due to the small number of patients with local recurrence and limited availability of tissue samples.
Limitations
The small sample size limits the generalizability of the results and the ability to perform multivariate analyses.
Participant Demographics
Patients were women with locally advanced cervical cancer (LACC) stages IIB–IVA.
Statistical Information
P-Value
0.004
Statistical Significance
p=0.004
Digital Object Identifier (DOI)
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