Hyperoxia Improves Kidney Function After Transplant
Author Information
Author(s): Kamran Montazeri, Mohammadali Vakily, Azim Honarmand, Parviz Kashefi, Mohammadreza Safavi, Shahram Taheri, Bahram Rasoulian
Primary Institution: Isfahan University of Medical Sciences
Hypothesis
Does intermittent exposure to hyperoxia improve renal function in living kidney donors after transplantation?
Conclusion
Intermittent exposure to hyperoxia in living kidney donors improves early renal function after kidney transplantation.
Supporting Evidence
- Mean creatinine clearance on posttransplant day 10 was significantly better in the oxygen group.
- Need for additional diuretics in the first 24 hours was significantly less in the oxygen group.
- Urine output during the first 6 hours after operation was significantly higher in the oxygen group.
- Duration of hospital stay was significantly shorter in the oxygen group.
Takeaway
Breathing in extra oxygen before donating a kidney can help the kidney work better after it's transplanted.
Methodology
Sixty living kidney donors were randomly assigned to receive either oxygen or air before transplantation, and various kidney function metrics were measured post-surgery.
Limitations
The study did not investigate the role of each factor separately affecting renal function.
Participant Demographics
Donors aged 18-55, healthy individuals; recipients aged 18-65 with end-stage renal disease.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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