Comparing Bisphenol A Levels in Monkeys and Mice
Author Information
Author(s): Taylor Julia A., vom Saal Frederick S., Welshons Wade V., Drury Bertram, Rottinghaus George, Hunt Patricia A., Toutain Pierre-Louis, Laffont Céline M., VandeVoort Catherine A.
Primary Institution: University of Missouri–Columbia
Hypothesis
How do bisphenol A pharmacokinetics in rhesus monkeys compare to those in mice, and what does this mean for human exposure?
Conclusion
BPA pharmacokinetics in women, female monkeys, and mice is very similar, suggesting that total daily human exposure is much higher than previously assumed.
Supporting Evidence
- BPA pharmacokinetics in monkeys and mice were found to be very similar.
- The average 24-hr unconjugated serum BPA concentration was 0.5 ng/mL in both monkeys and mice.
- Daily human exposure to BPA is likely much higher than previously estimated.
- Monkeys and mice cleared unconjugated serum BPA at virtually identical rates.
- Significant differences in BPA metabolism between humans and rodents were highlighted.
Takeaway
This study looked at how a chemical called BPA is processed in monkeys and mice, finding that both clear it from their bodies at similar rates, which helps us understand human exposure better.
Methodology
The study involved administering BPA to rhesus monkeys and mice and measuring serum levels over 24 hours using liquid chromatography–mass spectrometry.
Potential Biases
Potential bias may arise from the selection of animal models and the specific doses administered.
Limitations
The study primarily focused on female subjects, which may limit the generalizability of the findings to males.
Participant Demographics
Eleven adult female rhesus macaques and adult female CD-1 mice were used in the study.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website