Gene Prospector: A Tool for Finding Disease-Related Genes
Author Information
Author(s): Yu Wei, Wulf Anja, Liu Tiebin, Khoury Muin J, Gwinn Marta
Primary Institution: National Office of Public Health Genomics, Centers for Disease Control and Prevention
Hypothesis
Can a web-based application effectively prioritize potential disease-related genes using a curated literature database?
Conclusion
Gene Prospector is an effective online tool for searching evidence about human genes related to diseases and provides links to relevant literature.
Supporting Evidence
- Gene Prospector included more published genetic association studies for the 13 leading candidate genes than PDGene did.
- Nine of the thirteen leading candidate genes from PDGene were in the top 10th percentile of the ranked list from Gene Prospector.
- Gene Prospector provides links to additional data sources for further research.
Takeaway
Gene Prospector helps scientists find important genes that might cause diseases by looking at lots of research papers. It's like a search engine for gene information!
Methodology
Developed a web-based application that ranks genes based on the amount of published literature related to genetic associations.
Limitations
The application relies on the quality and availability of published literature, which may not cover all relevant studies.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website