The Role of GSK-3β in ALS
Author Information
Author(s): Koh Seong-Ho, Baek Wonki, Kim Seung H.
Primary Institution: Department of Neurology, College of Medicine Hanyang University
Hypothesis
The disturbance of signaling proteins upstream of GSK-3β might cause overactivation or overexpression of GSK-3β in ALS.
Conclusion
GSK-3β plays extremely important roles in motoneuronal cell death related to ALS, and the development of specific GSK-3 inhibitors might be an effective strategy for the treatment of ALS.
Supporting Evidence
- GSK-3β is increased in the thoracic spinal cord tissue of patients with sporadic ALS.
- Inhibition of GSK-3β reduces motor neuronal cell death in ALS models.
- GSK-3β inhibition can suppress disease progression of ALS in both in vitro and in vivo models.
Takeaway
GSK-3β is a protein that can cause nerve cells to die in ALS, and finding ways to block it could help treat the disease.
Methodology
This is a review article discussing the role of GSK-3β in ALS based on various studies.
Limitations
The review does not provide new experimental data and relies on existing literature.
Digital Object Identifier (DOI)
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