Stability of Bimatoprost vs. Latanoprost in Patient Use
Author Information
Author(s): Paolera Mauricio D, Kasahara Niro, Umbelino Cristiano C, Walt John G
Primary Institution: Private practice, São Paulo, Brazil; Global Health Outcomes Strategy & Research, Allergan, Inc., Irvine, CA, USA
Hypothesis
Does the storage and use of bimatoprost and latanoprost affect the degradation rate of their active ingredients?
Conclusion
Bimatoprost maintained its concentration while latanoprost degraded during normal patient use.
Supporting Evidence
- Bimatoprost bottles retained a mean percentage of labeled concentration of 103.7%.
- Only 8.8% of latanoprost bottles maintained at least 100% of their labeled concentration.
- The study was conducted in a hot, dry climate which may affect drug stability.
Takeaway
Bimatoprost stays effective longer than latanoprost when used by patients, which is important for keeping eye pressure low.
Methodology
Open-label study evaluating the stability of bimatoprost and latanoprost by collecting used bottles from patients.
Limitations
Baseline concentrations of the drugs were not measured prior to patient use.
Participant Demographics
Patients using bimatoprost (n=31) or latanoprost (n=34) in São Paulo, Brazil.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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