Staged Nipple Delay Procedure Expands Candidacy for Nipple-Sparing Mastectomy
Author Information
Author(s): Wang Xuanji MD, Jackson Jordan MD, Weed Christina MD, MPH, Boyle Marissa K. MD, Amersi Farin F. MD, Mirocha James MS, Giuliano Armando E. MD, Chung Alice P. MD
Primary Institution: Cedars-Sinai Medical Center, Los Angeles, CA USA
Hypothesis
Does the nipple delay procedure improve outcomes for patients undergoing nipple-sparing mastectomy?
Conclusion
Despite having more risk factors, patients who underwent the nipple delay procedure had very low rates of necrosis and no nipple loss.
Supporting Evidence
- ND-NSM patients had larger breasts compared to NSM patients.
- ND-NSM patients had a lower incidence of NAC necrosis compared to NSM patients.
- Prior breast/chest wall radiation was associated with increased risk for skin-flap necrosis.
Takeaway
This study shows that a special procedure can help more people safely keep their nipples during breast surgery.
Methodology
The study compared outcomes between patients who underwent nipple delay-nipple-sparing mastectomy and those who had nipple-sparing mastectomy alone from 2009 to 2023.
Potential Biases
The lack of randomization may introduce bias in the results.
Limitations
This was a single-center retrospective review, which may limit the generalizability of the findings.
Participant Demographics
Patients included those with cancer diagnoses and high-risk genetic mutation carriers undergoing prophylactic mastectomies.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI 1.01–1.35
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website