Photodynamic Therapy for Mesothelioma and Mammary Carcinoma in Mice
Author Information
Author(s): S.L. Gibson, T.H. Foster, R.H. Feins, R.F. Raubertas, M.A. Fallon, R. Hilf
Primary Institution: University of Rochester, School of Medicine and Dentistry
Hypothesis
Is the human mesothelioma xenograft more sensitive to photodynamic therapy than the rat mammary carcinoma in the same host?
Conclusion
The human mesothelioma xenograft is significantly more responsive to photodynamic therapy than the rat mammary carcinoma.
Supporting Evidence
- The mesothelioma xenograft showed a significant delay in tumor growth compared to the rat mammary carcinoma.
- Photodynamic therapy was fluence rate- and fluence-dependent for mesothelioma but not for the rat tumor.
- Both tumors had equivalent uptake of the photosensitizer, but their responses to therapy differed significantly.
Takeaway
This study found that a type of light therapy works much better on human mesothelioma tumors than on rat breast tumors when tested in mice.
Methodology
The study compared the effectiveness of photodynamic therapy on human mesothelioma and rat mammary carcinoma xenografts in nude mice, measuring tumor growth and response to treatment.
Limitations
The study was limited to two specific tumor types and may not generalize to other cancers.
Participant Demographics
Nude mice were used as hosts for the xenografts.
Statistical Information
P-Value
p<0.004
Statistical Significance
p<0.004
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