Calotropis procera Latex Extract Reduces Inflammation in Rats
Author Information
Author(s): Vijay L. Kumar, Sanjeev Roy
Primary Institution: All India Institute of Medical Sciences, New Delhi, India
Hypothesis
The study evaluates the protective effect of Calotropis procera latex extract against inflammation and oxidative stress in monoarthritis induced by Freund's complete adjuvant in rats.
Conclusion
Calotropis procera latex extract significantly reduces inflammation and oxidative stress in rats with induced monoarthritis.
Supporting Evidence
- Calotropis procera latex extract significantly reduced joint inflammation in a dose-dependent manner.
- The extract normalized levels of inflammatory mediators and oxidative stress parameters.
- Rofecoxib was found to be more effective than Calotropis procera in reducing inflammation.
Takeaway
This study shows that a plant called Calotropis procera can help reduce swelling and pain in rats with arthritis.
Methodology
The study involved injecting Freund's complete adjuvant into rats to induce monoarthritis and then treating them with different doses of Calotropis procera latex extract and comparing the effects with standard anti-inflammatory drugs.
Limitations
The study was conducted only on rats, and results may not directly translate to humans.
Participant Demographics
5-6-month-old Wistar rats of either sex weighing 150–180 g.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
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