Attenuation by all-trans-retinoic acid of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine in Wistar rats
1999
Effect of all-trans-retinoic acid on stomach cancer in rats
publication
Author Information
Author(s): Tatsuta M, Iishi H, Baba M, Hirasawa R, Yano H, Sakai N, Nakaizumi A
Primary Institution: Osaka Medical Center for Cancer and Cardiovascular Diseases
Hypothesis
Does all-trans-retinoic acid reduce gastric cancer induced by sodium chloride and a carcinogen in Wistar rats?
Conclusion
All-trans-retinoic acid significantly reduces the incidence of gastric cancers enhanced by sodium chloride in Wistar rats.
Supporting Evidence
- Long-term administration of all-trans-retinoic acid significantly reduced the incidence of gastric cancers.
- Sodium chloride significantly increased the incidence of gastric cancers compared to untreated controls.
- All-trans-retinoic acid decreased the labelling index and TGF-α immunoreactivity of gastric cancers.
Takeaway
Giving rats a substance called all-trans-retinoic acid helps lower the chances of them getting stomach cancer when they also eat a lot of salt.
Methodology
Wistar rats were treated with a carcinogen and given sodium chloride and all-trans-retinoic acid to observe effects on gastric cancer development.
Participant Demographics
Wistar rats
Digital Object Identifier (DOI)
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