Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock
2011
Understanding How Superantigens Cause Toxic Shock
publication
Evidence: moderate
Author Information
Author(s): Arad G, Levy R, Nasie I, Hillman D, Rotfogel Z
Hypothesis
The study investigates the role of CD28 in the mechanism of superantigen toxicity.
Conclusion
The findings reveal that superantigens bind to CD28, which is essential for their toxic effects.
Supporting Evidence
- Superantigens can bind to CD28, which enhances their toxic effects.
- Mutations in the CD28 binding site on superantigens reduce their ability to stimulate T cells.
- Synthetic peptides that block superantigen binding to CD28 can protect against toxic shock.
Takeaway
Superantigens are bad proteins that can make you very sick by tricking your immune system, and they need a special helper called CD28 to do this.
Methodology
The study used mutagenesis and peptide phage display techniques to explore the binding interactions of superantigens with CD28.
Limitations
The study primarily focused on cytokine production without assessing T cell proliferation.
Digital Object Identifier (DOI)
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