Ammonium Sensing Patch for Body Fluids Analysis

Sample size: 26 publication 10 minutes Evidence: high

Author Information

Author(s): Mingli Huang, Xiaohao Ma, Zongze Wu, Jirong Li, Yuqing Shi, Teng Yang, Jiarun Xu, Shuhan Wang, Kongpeng Lv, Yuanjing Lin

Primary Institution: Southern University of Science and Technology

Can a flexible and biocompatible sensing patch accurately monitor ammonium levels in various body fluids?

The developed ammonium sensing patch shows high sensitivity and reliability for monitoring ammonium levels in body fluids.

The sensors can detect NH4+ with a sensitivity of 58.7 mV decade−1.
The detection range is from 1 μM to 100 mM, suitable for various body fluids.
The average detection error was 13.2%, with improved accuracy after cross-calibration.
The sensors showed good biocompatibility with cell growth rates over 80% on the sensor surface.
The hemolysis rate was less than 5%, indicating minimal toxicity.
The sensors maintained stable performance after multiple bending cycles.
The patch was able to wirelessly transmit data for real-time monitoring.
The study demonstrated the potential for in vivo applications in continuous health monitoring.

Scientists created a special patch that can check how much ammonium is in our body fluids, like sweat and blood, without hurting us.

The study involved developing a flexible and biocompatible patch with NH4+ and K+ sensors for wireless monitoring of ammonium levels in body fluids.

The long-term stability of the sensor may be affected by contamination and damage from blood and interstitial fluid.

Healthy C57BL/6 male mice were used for in vivo testing.

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