Prognostic Value of p27Kip1 in Laryngeal Basaloid Squamous Cell Carcinoma
Author Information
Author(s): Salerno Grazia, Di Vizio Dolores, Staibano Stefania, Mottola Giampiero, Quaremba Giuseppe, Mascolo Massimo, Galli Vieri, De Rosa Gaetano, Insabato Luigi
Primary Institution: University Federico II, Naples, Italy
Hypothesis
The study investigates the prognostic value of p27kip1 levels and their correlation with Ki67/Mib-1 and p53 expression in Basaloid Squamous Cell Carcinoma of the larynx.
Conclusion
p27kip1 protein is a significant independent prognostic factor in laryngeal SCC, with low expression correlating with poor prognosis.
Supporting Evidence
- 40% of patients with no evidence of disease had high p27kip1 expression.
- 0% of patients dead of disease had high p27kip1 expression.
- 60% of patients in NED status expressed p53, while 90% of DOD patients expressed it.
- 80% of NED patients were positive for Ki67/Mib-1, compared to 100% of DOD patients.
Takeaway
This study found that low levels of a protein called p27kip1 in certain throat cancers can mean a worse outcome for patients.
Methodology
The study analyzed paraffin-embedded tissue sections for p27kip1, Ki67/Mib-1, and p53 expression using immunohistochemistry in a retrospective cohort of patients.
Limitations
The study is limited by its small sample size and retrospective design.
Participant Demographics
The cohort consisted of 15 male and 1 female patients, aged 44 to 69 years, with a mean age of 58.
Statistical Information
P-Value
0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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