Dietary Lignans and Breast Cancer Risk in Postmenopausal Women
Author Information
Author(s): Suzuki R, Rylander-Rudqvist T, Saji S, Bergkvist L, Adlercreutz H, Wolk A
Primary Institution: Karolinska Institute
Hypothesis
Is there an association between dietary lignan intake and breast cancer risk among postmenopausal women?
Conclusion
Higher dietary lignan intake is associated with a significant reduction in breast cancer risk, particularly among women who use postmenopausal hormones.
Supporting Evidence
- A significant 17% risk reduction for breast cancer was observed in women with high lignan intake.
- The study found no heterogeneity across estrogen and progesterone receptor subtypes.
- Women with high lignan intake tended to be older and have more education.
Takeaway
Eating more foods with lignans, like certain grains and vegetables, might help lower the risk of breast cancer for older women.
Methodology
The study used a prospective cohort design with food-frequency questionnaires to estimate lignan intake and followed participants for breast cancer diagnosis.
Potential Biases
The study may have non-differential misclassification of exposure due to dietary assessment methods.
Limitations
Potential nutrient misclassification and individual variation in intestinal microflora may affect the results.
Participant Demographics
The study included 51,823 postmenopausal women from the Swedish Mammography Cohort.
Statistical Information
P-Value
p<0.0001
Confidence Interval
0.70–0.97
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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