Effects of Nicotinates and Benzalkonium Chloride on Blood Flow in Porcine Skin
Author Information
Author(s): H. D. Moore, F. M. Cunningham
Primary Institution: The Royal Veterinary College
Hypothesis
The study investigates the role of prostaglandins and interleukin-1 in the blood flow response to hexyl-nicotinate and benzalkonium chloride in porcine skin.
Conclusion
Both hexyl-nicotinate and benzalkonium chloride significantly increased blood flow in porcine skin, with the response to benzalkonium chloride being more prolonged.
Supporting Evidence
- Topical application of hexyl-nicotinate and benzalkonium chloride caused significant increases in blood flow compared to the vehicle.
- The time to reach maximum blood flow was consistent across all animals.
- Flunixin meglumine treatment significantly reduced the blood flow response to hexyl-nicotinate.
Takeaway
When certain chemicals are put on pig skin, they make the blood flow more, which is similar to what happens in human skin.
Methodology
The study involved applying hexyl-nicotinate and benzalkonium chloride to mini-pig skin and measuring blood flow responses using a laser Doppler flowmeter.
Limitations
The variability in blood flow responses among individual pigs may affect the results.
Participant Demographics
Mini-pigs (Gottingen strain; 15-25 kg)
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.001
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