Mutants in the Mouse NuRD/Mi2 Component P66α Are Embryonic Lethal Mutants in the Mouse P66α Gene
2007
Mouse P66α Gene is Essential for Embryonic Development
Sample size: 375
publication
10 minutes
Evidence: high
Author Information
Author(s): Marino Susan Nusse, Roel Rutherford
Primary Institution: Howard Hughes Medical Institute, Stanford University School of Medicine
Hypothesis
Is the p66α gene essential for normal embryonic development in mice?
Conclusion
The p66α gene is essential for early mouse development, as its absence leads to embryonic lethality.
Supporting Evidence
- Mutant embryos die around day 10 of embryogenesis.
- The gene is not required for normal blastocyst development or implantation.
- No mp66α homozygous mutant pups were found among the analyzed animals.
Takeaway
The p66α gene is very important for baby mice to grow properly before they are born; without it, they can't survive.
Methodology
Loss of function mutants were created in the mouse p66α gene, and the resulting embryos were analyzed for development.
Limitations
The study primarily focuses on the p66α gene without exploring potential interactions with other genes.
Participant Demographics
Mouse embryos were used in the study.
Digital Object Identifier (DOI)
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