Study of RON Receptor in Gastric Cancer
Author Information
Author(s): Zhou Donghui, Pan Gang, Zheng Chen, Zheng Jingjing, Yian Liping, Teng Xiaodong
Primary Institution: The First Affiliated Hospital of College of Medicine of Zhejiang University
Hypothesis
RON and its splice variant play an important role in the occurrence, progression, and metastasis of gastric carcinoma.
Conclusion
RON expression is significant in gastric carcinoma tissue and corresponding paraneoplastic tissue, but is not expressed in normal gastric mucosa.
Supporting Evidence
- RON expression was observed in 56.1% of gastric carcinoma tissues.
- RON expression positively correlated with the invasive depth of the tumor.
- RON expression was independent of tumor growth pattern and histopathological grade.
Takeaway
This study found that a protein called RON is present in stomach cancer but not in healthy stomach tissue, which might help doctors understand and treat the cancer better.
Methodology
Immunohistochemistry and Western blot analysis were used to examine RON expression in gastric carcinoma and normal tissues.
Limitations
The follow-up data was not sufficient to provide additional insight into which factors might be important for survival rates.
Participant Demographics
70 men and 28 women, aged 21 to 76 years (median age 58 years).
Statistical Information
P-Value
p = 0.007
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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