Reference Ranges for Heart Measurements in Sickle Cell Disease Patients
Author Information
Author(s): Pistoia Laura, Meloni Antonella, Positano Vincenzo, Quota Alessandra, Corigliano Elisabetta, Messina Giuseppe, Renne Stefania, Zerbini Michela, Romani Simona, Sinagra Gianfranco, Ait Ali Lamia, Mavrogeni Sophie, Lupi Amalia, Cademartiri Filippo, Pepe Alessia
Primary Institution: Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy
Hypothesis
This study aims to establish biatrial and biventricular reference ranges using cardiac magnetic resonance parameters in sickle cell disease patients without heart damage.
Conclusion
The study found that sickle cell disease patients without cardiac damage have significantly higher biatrial and biventricular measurements compared to healthy controls.
Supporting Evidence
- Male sickle cell disease patients showed significantly higher left ventricular end-diastolic volume index than healthy subjects.
- Female sickle cell disease patients exhibited increased left ventricular stroke volume index compared to healthy controls.
- Sickle cell disease and thalassemia major patients showed comparable biatrial areas and biventricular volumes.
Takeaway
Doctors measured the hearts of sickle cell disease patients to understand what normal looks like, so they can better spot heart problems in these patients.
Methodology
The study compared cardiac magnetic resonance parameters in 48 adult sickle cell disease patients to matched cohorts of healthy controls and thalassemia major patients.
Potential Biases
The data were derived from a single database, which may limit the applicability of the findings to other populations.
Limitations
The study had a relatively small sample size and did not consider the impact of endocrine complications or HCV infection on ventricular function.
Participant Demographics
The study included 48 adult sickle cell disease patients, with a mean age of 36.95 years, including 28 females.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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