Understanding Nuclear Receptor Interactions
Author Information
Author(s): Gregory D Amoutzias, Elgar E Pichler, Nina Mian, David L De Graaf, Anastasia Imsiridou, Marc Robinson-Rechavi, Erich Bornberg-Bauer, David L Robertson, Stephen G Oliver
Primary Institution: Faculty of Life Sciences, University of Manchester
Hypothesis
The study aims to elucidate the dimerization network of nuclear receptors and its implications for gene regulation.
Conclusion
The nuclear receptor interaction network is more connected than previously thought, with a hub-based topology and significant negative feedback loops.
Supporting Evidence
- The study retrieved over 70,000 articles related to nuclear receptors.
- A total of 179 nuclear receptor protein-protein interactions were identified.
- Gene expression data validated 99 out of 125 heterodimerizing interactions in humans.
Takeaway
Nuclear receptors work together in pairs to control many genes, and this study shows how they interact in a complex network.
Methodology
The study integrated phylogeny, protein-protein interactions, protein-DNA interactions, and gene expression data through semi-automated text-mining and manual curation.
Limitations
The study may not capture all interactions due to the vast literature and varying levels of evidence for interactions.
Digital Object Identifier (DOI)
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