Study of New Markers in Breast Cancer
Author Information
Author(s): Simony-Lafontaine J, Esslimani M, Bribes E, Gourgou S, Lequeux N, Lavail R, Grenier J, Kramar A, Casellas P
Primary Institution: Montpellier Cancer Institute, Montpellier, France
Hypothesis
The study investigates the relationship between sigma-1 receptor and human sterol isomerase with various prognostic factors in breast cancer patients.
Conclusion
The sigma-1 receptor and human sterol isomerase may serve as new markers to identify breast cancer patients who could benefit from adjuvant therapy.
Supporting Evidence
- The sigma-1 receptor expression was closely correlated with hormonal receptor positivity (P = 0.008).
- There was an inverse relationship between hSI expression and the oestrogen/progesterone receptor positivity (P = 0.098).
- A significant relationship was shown between sigma-1 receptor and Bcl2 expression (P = 0.017).
- The presence of hSI and absence of sigma-1 receptor were linked to poorer disease-free survival (P = 0.007).
Takeaway
Researchers looked at two new markers in breast cancer to see if they could help doctors decide on treatments. They found that these markers might help identify patients who need extra therapy.
Methodology
Immunocytochemical investigation of sigma-1 receptor and human sterol isomerase in breast cancer patients.
Participant Demographics
Patients with operable primary breast cancers.
Statistical Information
P-Value
0.007
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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