Verapamil: what is the mechanism of its anticarcinogenic activity?
1994
Verapamil and Its Role in Preventing Liver Cancer
Commentary
Author Information
Author(s): G. Brambilla
Primary Institution: University of Genoa
Hypothesis
Can verapamil reverse the resistance of preneoplastic hepatocytes to carcinogens?
Conclusion
Verapamil may hinder the formation of liver cancer by reducing the resistance of certain liver cells to carcinogens.
Supporting Evidence
- Verapamil has been shown to antagonize multidrug resistance in various cell lines.
- Treatment with carcinogens increases liver RNA levels for proteins that handle hepatotoxins.
Takeaway
Verapamil might help prevent liver cancer by making it harder for bad cells to grow and multiply.
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