The Utility of Cyclodextrin for Countering μ-Opioid Receptor Drug Overdoses
2024
Using Cyclodextrin to Help with Opioid Overdoses
publication
Evidence: moderate
Author Information
Author(s): Ogawa Noriko
Primary Institution: Department of Pharmacy, College of Pharmacy, Kinjo Gakuin University
Hypothesis
Can a new cyclodextrin derivative effectively counteract opioid overdoses?
Conclusion
The study suggests that SBX-Me could shorten recovery times from opioid overdoses in rats.
Supporting Evidence
- SBX-Me shortened recovery time from fentanyl exposure in rats from approximately 35 to 17 minutes.
- SBX-Me also reduced recovery time from carfentanil from approximately 172 to 59 minutes.
- The study indicates that SBX-Me might prevent opioids from interacting with their target receptors.
Takeaway
Scientists are testing a new substance that might help people recover faster from opioid overdoses by trapping the drugs in the body.
Methodology
The study involved administering SBX-Me to rats exposed to various opioids and measuring recovery times.
Limitations
The stability constant of SBX-Me with fentanyl was not provided, and it may not completely capture fentanyl before it crosses the blood-brain barrier.
Participant Demographics
Rats were used in the study.
Digital Object Identifier (DOI)
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