Nephrocalcinosis in Very Preterm Infants: Study on Incidence and Vitamin D Intake
Author Information
Author(s): Garunkstiene Rasa, Levuliene Ruta, Cekuolis Andrius, Cerkauskiene Rimante, Drazdiene Nijole, Liubsys Arunas, Fingerhut Ralph
Primary Institution: Vilnius University Hospital Santaros Klinikos
Hypothesis
What are the incidence and risk factors of nephrocalcinosis in very preterm infants, and how does vitamin D intake in the first month affect it?
Conclusion
Nephrocalcinosis is common in very preterm infants, particularly those with lower gestational age, and careful vitamin D supplementation is important for their health.
Supporting Evidence
- Nephrocalcinosis was found in 35% of the cohort of 160 infants.
- Risk factors for nephrocalcinosis included lower gestational age and higher morbidity.
- At 28 days, serum vitamin D levels were significantly different between the nephrocalcinosis and control groups.
Takeaway
This study found that many very preterm babies have a kidney condition called nephrocalcinosis, and giving them the right amount of vitamin D can help keep their bones healthy.
Methodology
This was a prospective observational study comparing data from infants with nephrocalcinosis and a control group based on kidney ultrasound results.
Potential Biases
Potential bias due to non-standardized management of vitamin D and milk fortification.
Limitations
The study was conducted at a single center, lacked standardized vitamin D management, and did not include genetic testing.
Participant Demographics
Infants born at less than 32 weeks gestation, with a mean gestational age of 27.59 weeks.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI 0.110–0.425
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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