Improving Curcumin Delivery with Plant Crystals and Extracellular Vesicles
Author Information
Author(s): Muzn Alkhaldi, Tehseen Sehra, Soma Sengupta, Cornelia M. Keck
Primary Institution: Philipps-Universität Marburg
Hypothesis
The encapsulation of curcumin in extracellular vesicles (EVs) and plantCrystals (PCEVs) will lead to better physical stability and increased penetration efficacy of curcumin.
Conclusion
Curcumin-loaded PCEVs are more effective than curcumin-added PCEVs and curcumin-loaded EVs for dermal delivery.
Supporting Evidence
- Curcumin-loaded PCEVs achieved a 1.5-fold increase in penetration efficacy compared to curcumin-added PCEVs.
- Curcumin-loaded PCEVs showed superior penetration depth compared to curcumin-loaded EVs.
- Particle-assisted dermal penetration was observed with larger curcumin particles in the formulations.
Takeaway
This study found that using special plant particles can help a medicine called curcumin get into the skin better, which is important for treating skin problems.
Methodology
The study used classical isolation methods for EVs and bead milling for PCEVs, followed by characterization of physicochemical properties and evaluation of dermal penetration efficacy using ex vivo porcine ear models.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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