Unexpectedly long incubation period of Plasmodium vivax malaria, in the absence of chemoprophylaxis, in patients diagnosed outside the transmission area in Brazil
2011

Long Incubation Period of Plasmodium vivax Malaria in Brazil

Sample size: 80 publication Evidence: moderate

Author Information

Author(s): Patrícia Brasil, Anielle de Pina Costa, Renata Saraiva, Clarisse Bressan, Sidnei da Silva, Pedro Luiz Tauil, Cláudio Tadeu Daniel-Ribeiro

Primary Institution: Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro

Hypothesis

Can the incubation period of Plasmodium vivax malaria be extended in patients diagnosed outside the transmission area?

Conclusion

The study found that some patients experienced an incubation period for P. vivax malaria that was significantly longer than previously documented.

Supporting Evidence

  • 63% of the patients diagnosed with malaria were infected with P. vivax.
  • Seven patients had an estimated incubation period of 3 to 12 months.
  • None of the patients had taken malaria chemoprophylaxis.

Takeaway

Some people can get malaria symptoms a long time after they come back from a trip, even if they didn't take medicine to prevent it.

Methodology

Descriptive study analyzing malaria patients who visited the clinic over five years.

Limitations

The study did not include children and relied on patient recall for exposure dates.

Participant Demographics

Patients were travelers, primarily from the Amazon region, with a mix of previous malaria history.

Digital Object Identifier (DOI)

10.1186/1475-2875-10-122

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