Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3
1999
Mutation Analysis of the Fanconi Anaemia A Gene in Breast Tumours
Sample size: 19
publication
Evidence: low
Author Information
Author(s): Cleton-Jansen A-M, Moerland E W, Pronk J C, van Berkel C G M, Apostolou S, Crawford J, Savoia A, Auerbach A D, Mathew C G, Callen D F, Cornelisse C J
Primary Institution: Leiden University Medical Center
Hypothesis
Is the Fanconi anaemia A gene involved in breast cancer with loss of heterozygosity at 16q24.3?
Conclusion
The FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer.
Supporting Evidence
- The FAA gene is located on chromosomal band 16q24.3.
- Loss of heterozygosity at 16q24.3 is frequently reported in breast cancer.
- Five polymorphisms were identified but did not differ from normal controls.
Takeaway
The study looked at a gene thought to be linked to breast cancer but found it wasn't involved.
Methodology
Mutation analysis using SSCP and Southern blotting.
Limitations
The study did not identify any tumour-specific mutations.
Digital Object Identifier (DOI)
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