Rrd1 Regulates RNA Polymerase II during Stress
Author Information
Author(s): Jeremie Poschmann, Simon Drouin, Pierre-Etienne Jacques, Karima El Fadili, Michael Newmarch, François Robert, Dindial Ramotar
Primary Institution: Department of Medicine, Maisonneuve-Rosemont Hospital, Research Center, University of Montreal, Montréal, Québec, Canada
Hypothesis
How does Rrd1 regulate transcription by RNA Polymerase II during transcriptional stresses?
Conclusion
Rrd1 is a novel transcription elongation factor that fine-tunes the transcriptional stress response of RNA Polymerase II.
Supporting Evidence
- Rrd1 colocalizes with RNA Polymerase II on actively transcribed genes.
- Deletion of Rrd1 affects RNA Polymerase II occupancy on rapamycin responsive genes.
- Rrd1 is required for the optimal up and down regulation of RNA Polymerase II levels during rapamycin response.
Takeaway
Rrd1 helps a cell's machinery read genes correctly when it's under stress, like when there's not enough food or when it's getting hurt by chemicals.
Methodology
The study used ChIP-chip analysis to map Rrd1 and RNA Polymerase II occupancy in yeast under different conditions.
Limitations
The study primarily focuses on yeast, which may limit the generalizability of the findings to other organisms.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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