Promoter Class Changes in Yeast Evolution
Author Information
Author(s): Bazykin Georgii A, Kondrashov Alexey S
Primary Institution: Princeton University
Hypothesis
How do promoter classes switch during the evolution of yeast species?
Conclusion
Promoters in yeast can switch classes at a significant rate, indicating that key transcription sequences evolve rapidly.
Supporting Evidence
- 212 genes were identified with class 1 promoters in S. cerevisiae.
- 44 genes with class 2 promoters in S. cerevisiae had TATA boxes in other species.
- Promoter class switches occurred at a rate of one per 8-20 nucleotide substitutions.
Takeaway
Some genes in yeast can change their 'address' for starting to make proteins, which can happen quite often over time.
Methodology
The study compared upstream non-coding regions of orthologous genes from five species of Saccharomyces to determine promoter class switches.
Potential Biases
Potential biases may arise from the reliance on sequence data without experimental validation for non-cerevisiae species.
Limitations
The conclusions are based on a limited number of genes and may not apply universally across all yeast species.
Participant Demographics
The study focused on five species of the Saccharomyces genus.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website