Tissue-selective therapy of cancer
2003
Tissue-selective therapy of cancer
publication
Evidence: moderate
Author Information
Author(s): M V Blagosklonny
Primary Institution: New York Medical College
Hypothesis
Can therapeutic agents be designed in a tissue-specific fashion to attack normal differentiated cells?
Conclusion
Tissue-selective therapy can effectively target cancer cells while minimizing side effects, but it may also promote the development of resistant cancer cells.
Supporting Evidence
- Tissue-selective therapy targets cancer cells and some normal cells of the same tissue, leading to fewer side effects.
- Hormonal therapy has an excellent response rate but can promote hormone-independent disease.
- Glucocorticoids are effective in treating leukemia but can lead to resistant clones.
Takeaway
This study talks about how some cancer treatments can target specific tissues, which helps reduce side effects but can also make the cancer harder to treat later.
Limitations
Tissue-selective therapy may lead to the selection of resistant cancer cells.
Digital Object Identifier (DOI)
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