Acute Kidney Injury in Major Burns
Author Information
Author(s): Ingrid Steinvall, Zoltan Bak, Fredrik Sjoberg
Primary Institution: Linköping University Hospital
Hypothesis
Acute kidney injury is common and develops soon after a major burn.
Conclusion
Acute kidney injury is common, develops soon after the burn, and is paralleled by other organ dysfunctions.
Supporting Evidence
- 31 out of 127 patients developed acute kidney injury, which is about 24%.
- Mortality increased with the severity of acute kidney injury, reaching 83% in the Failure class.
- Renal dysfunction occurred within 7 days in 55% of the patients.
Takeaway
When people get serious burns, their kidneys can get hurt quickly, but most of them can get better if they survive.
Methodology
This was a prospective exploratory cohort study on patients with burns covering 20% or more of total body surface area, assessing acute kidney injury using the RIFLE classification.
Potential Biases
Potential selection bias from excluding patients with the worst and best outcomes.
Limitations
The study excluded patients who died within the first 2 days and those with superficial burns, which may affect the generalizability of the findings.
Participant Demographics
Mean age was 40.6 years, with 25% being women.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 36.7 to 44.5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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