1-(Piperidin-1-yl)-3-(2,4,6-trimethylÂphenÂyl)propan-2-ol
2011
Study of a New Compound with Piperidine
publication
Evidence: moderate
Author Information
Author(s): Maharramov Abel M., Khalilov Ali N., Gurbanov Atash V., Allahverdiyev Mirze A., Ng Seik Weng
Primary Institution: Baku State University
Hypothesis
The study investigates the synthesis of a compound similar to tolperisone using a cyclic secondary amine.
Conclusion
The compound C17H27NO was successfully synthesized and characterized, showing a unique hydrogen-bonded dimer structure.
Supporting Evidence
- The compound features a butterfly-shaped substituted 2-propanol.
- The piperidine ring adopts a chair conformation.
- The hydroxy group interacts with the N atom of an inversion-related molecule.
Takeaway
Researchers made a new chemical compound that could help with muscle relaxation, and they found out how its molecules stick together.
Methodology
The synthesis involved stirring 1-chloro-3-(2,4,6-trimethylphenyl)propan-2-one with piperidine in water for 18 hours.
Digital Object Identifier (DOI)
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