Comparing Methods for Measuring Gadolinium in the Heart
Author Information
Author(s): Janardhanan Rajesh, Jiji Ronny S, Brooks Jeremy, Epstein Frederick H, Kramer Christopher M, Salerno Michael
Primary Institution: University of Virginia, Charlottesville, VA, USA
Hypothesis
Can T1 mapping techniques accurately quantify myocardial fibrosis using different methods for determining the partition coefficient of gadolinium?
Conclusion
The 3-5 MOLLI sequence provides reliable T1 maps in a shorter breathhold and is comparable to the standard approach, while the 2-2-4 MOLLI sequence shows a bias towards lower T1 values pre-contrast.
Supporting Evidence
- The standard MOLLI and the 3-5 MOLLI sequences provided comparable T1 values for myocardium and blood.
- The 2-2-4 MOLLI sequence had a bias towards lower T1 values pre-contrast.
- There was good agreement between the partition coefficients of gadolinium for the CI method and the EPC method.
Takeaway
This study looked at different ways to measure how gadolinium behaves in the heart, finding that one method works just as well but is quicker and easier.
Methodology
T1 mapping was performed on 10 healthy volunteers using three MOLLI schemes and gadolinium injections.
Limitations
The 2-2-4 MOLLI sequence may have insufficient T1 relaxation between inversion pulses, leading to biased results.
Participant Demographics
Healthy volunteers, average age 34±11 years.
Statistical Information
P-Value
0.06 for blood pre-contrast, 0.11 for myocardium pre-contrast, 0.97 for blood post-contrast, 0.96 for myocardium post-contrast.
Digital Object Identifier (DOI)
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