Troponin-T and Mortality in Atrial Fibrillation Patients
Author Information
Author(s): Serkan Celik, Linus Bodeström Eriksson, Jakob Hytting, Annette Waldemar, Panagiotis Mallios, Amanda Berggren, Ellen Oscarsson, Christofer Digerfeldt, Magnus Wijkman, Laila Hubbert
Primary Institution: Linkoping University
Hypothesis
Can age-adjusted hsTnT levels predict mortality in patients with atrial fibrillation attending the emergency department?
Conclusion
Elevated hsTnT levels increase the risk for 30-day and 1-year mortality independently of age.
Supporting Evidence
- All-cause mortality was 2% at 30 days and 8% at 1 year.
- Patients with hsTnT levels 15–50 ng/L had a hazard ratio of 4.82 for 1-year mortality.
- Patients with hsTnT levels >50 ng/L had a hazard ratio of 9.70 for 1-year mortality.
- Dyspnea was associated with increased mortality.
- Palpitations were associated with lower 1-year mortality.
Takeaway
If you have atrial fibrillation and high troponin-T levels, you might be at a higher risk of dying within a month or a year.
Methodology
This was a retrospective, single centre, register-based cohort study analyzing patients with atrial fibrillation who were sampled for hsTnT.
Potential Biases
Potential bias due to exclusion of patients not sampled for hsTnT based on clinical assessment.
Limitations
No differentiation was made between paroxysmal and persistent AF, and the study was limited to a single center.
Participant Demographics
Median age was 72 years, with 45% female participants.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 1.81–12.82
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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