Antibodies Against Phosphorylcholine and Cardiovascular Disease in Women
Author Information
Author(s): Frostegård Johan, Åkesson Agneta, Helte Emilie, Söderlund Fredrik, Su Jun, Hua Xiang, Rautiainen Susanne, Wolk Alicja
Primary Institution: Karolinska Institutet, Stockholm, Sweden
Hypothesis
High levels of IgM anti-PC are associated with lower risk of cardiovascular disease, particularly myocardial infarction, among women.
Conclusion
IgM anti-PC may inhibit the development of cardiovascular disease in women, especially myocardial infarction.
Supporting Evidence
- IgM anti-PC was inversely associated with risk of cardiovascular disease, ischemic heart disease, and myocardial infarction.
- Over 16 years, 113 cases of composite cardiovascular disease were identified.
- Participants in the highest tertile of IgM anti-PC had a multivariable-adjusted HR of 0.27 for myocardial infarction.
Takeaway
Women with higher levels of a specific antibody may have a lower chance of heart problems.
Methodology
The study measured IgM anti-PC levels in serum and assessed associations with cardiovascular disease using Cox proportional hazard regression.
Potential Biases
Observational design may introduce residual confounding.
Limitations
The study had a limited sample size and potential for unmeasured confounding.
Participant Demographics
Participants were women from the Swedish Mammography Cohort, average age 66 years.
Statistical Information
P-Value
<0.01
Confidence Interval
95% CI: 0.11-0.68
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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