CD73 Expression in Breast Cancer
Author Information
Author(s): K.H. Kruger, L.F. Thompson, M. Kaufmann, P. Moller
Primary Institution: Pathologisches Institut der Universitat Heidelberg
Hypothesis
This study aims at a more detailed analysis of CD73 expression among the different cell types constituting the mammary gland and at an investigation of possible changes in neoplastic transformation.
Conclusion
The study found that CD73 expression is lost in the majority of breast carcinomas, while stromal fibroblasts show variable expression that correlates with estrogen receptor status.
Supporting Evidence
- 93 out of 102 breast carcinomas were completely negative for CD73 expression.
- Only 9% of carcinoma cases expressed CD73 in tumor cells.
- 68% of tumors had completely and strongly CD73-positive fibroblasts in the stroma.
Takeaway
This study looked at a protein called CD73 in breast tissue and found that it is usually not present in cancer cells, but is often found in the surrounding tissue, especially in cases where the cancer is influenced by hormones.
Methodology
Immunohistochemical investigation of CD73 expression in normal and cancerous breast tissue using monoclonal antibodies.
Limitations
The study did not determine the exact extent of CD73 positivity in non-neoplastic compartments within carcinomas.
Participant Demographics
The study included 102 unselected primary malignant breast tumors from patients with varying ages and menopausal statuses.
Statistical Information
P-Value
p<0.038
Statistical Significance
p<0.038
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