Impact of Enhanced Recovery After Surgery on Inflammation in Laparoscopic Surgery
Author Information
Author(s): Alves Bersot Carlos Darcy, Ferreira Gomes Pereira Lucas, Goncho Victor Gabriel Vieira, Pereira José Eduardo Guimarães, Falcão Luiz Fernando dos Reis
Primary Institution: Department of Anesthesia, BP Hospital – A Beneficência Portuguesa de São Paulo, São Paulo, Brazil
Hypothesis
What research has been conducted on the impact of the ERAS recommendations on inflammatory markers in laparoscopic surgery, and what evidence is available regarding its effects on the immune system?
Conclusion
ERAS recommendations appear to beneficially modulate inflammatory responses in laparoscopic surgery, suggesting a potential for enhanced recovery outcomes.
Supporting Evidence
- ERAS guidelines could mitigate the inflammatory response, evidenced by reduced levels of CRP and IL-6.
- Findings consistently showed that ERAS recommendations lead to fewer postoperative complications.
- Most studies focused on laparoscopic colorectal surgeries.
Takeaway
This study looked at how certain guidelines can help patients recover better after laparoscopic surgery by reducing inflammation in their bodies.
Methodology
This scoping review analyzed studies from databases like PubMed, Scopus, and Cochrane Library, including randomized controlled trials and observational studies.
Potential Biases
There were risks of bias due to insufficient blinding of surgical teams and reliance on a limited number of small-scale studies.
Limitations
The evidence is currently limited by the small number of studies and inherent methodological biases.
Participant Demographics
The studies involved both male and female participants, with the ERAS group having a mean age of 59.7 years compared to 49.7 years in the control group.
Statistical Information
P-Value
p=0.02
Confidence Interval
−47.05 to −4.91
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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