ISCA1 and Its Role in Cancer and Ferroptosis
Author Information
Author(s): Xiong Dejun, Li Zhao, Zuo Ling, Ge Juan, Gu Yuhan, Zhang Erhao, Zhou Xiaorong, Yu Guiping, Sang Mengmeng, Bortoluzzi Stefania, Luo Xingguang
Primary Institution: Nantong University
Hypothesis
ISCA1 is involved in tumor progression through interactions with ferroptosis-related genes and the tumor immune microenvironment.
Conclusion
ISCA1 could serve as a biomarker for predicting prognosis and immunotherapeutic efficacy in thyroid carcinoma.
Supporting Evidence
- ISCA1 expression was significantly higher in various tumor tissues compared to normal tissues.
- ISCA1 was identified as a potential biomarker for thyroid carcinoma.
- ISCA1 RNA expression correlated with overall survival in multiple cancer types.
Takeaway
ISCA1 is a protein that helps cells manage iron and can affect how cancer cells die. This study found that ISCA1 might help doctors predict how well patients with thyroid cancer will respond to treatment.
Methodology
The study analyzed ISCA1 expression, CNV, methylation, and protein levels across various cancers using data from TCGA and CPTAC databases.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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