Infectious Disease Agents in Rodents in Zambia
Author Information
Author(s): S. M. Munjita, Kalonda Annie, Mubemba Benjamin, Vanaerschot Manu, Tato Cristina, Mwakibete Lusajo, Tembo John, Chitanga Simbarashe, Changula Katendi, Kajihara Masahiro, Muleya Walter, Sawa Hirofumi, Takada Ayato, Bates Matthew, Munsaka Sody, Simulundu Edgar
Primary Institution: University of Zambia
Hypothesis
What is the prevalence of viral, bacterial, and parasitic pathogens in Mastomys natalensis rodents in riverine and non-riverine areas in Zambia?
Conclusion
Mastomys natalensis rodents carry multiple infectious agents with zoonotic potential, particularly in riverine regions of Zambia.
Supporting Evidence
- 14 pathogens were detected in 10.4% of the rodent samples.
- Riverine areas showed higher odds of pathogen presence.
- Pathogens included zoonoses like Klebsiella pneumoniae and Salmonella enterica.
- Metagenomic next-generation sequencing was used for pathogen detection.
- Most pathogens were found in riverine habitats.
Takeaway
This study found that some rodents in Zambia can carry germs that can make people sick, especially in areas near rivers.
Methodology
The study used metagenomic next-generation sequencing to analyze tissues from captured rodents.
Potential Biases
Potential biases may arise from the non-systematic trapping approach and the ecological factors influencing pathogen presence.
Limitations
The study's trapping method was not systematic, which may affect the representativeness of the sample.
Participant Demographics
54.9% females and 45.1% males among the captured rodents.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 3.07–23.26
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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