Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice
2001
Monoclonal Antibody Prevents Mouth Damage from Doxorubicin in Mice
publication
Author Information
Author(s): Balsari A, Rumio C, Morelli D, Sfondrini L, Nardini E, Barajon I, Ménard S
Primary Institution: Institute of Pathology, Department of Human Anatomy, Faculty of Medicine, Milan University, Milan, Italy
Hypothesis
Can topical administration of a doxorubicin-specific monoclonal antibody prevent drug-induced mouth apoptosis in mice?
Conclusion
Topical application of anti-DXR monoclonal antibodies completely inhibited apoptosis in the tongue of doxorubicin-treated mice.
Supporting Evidence
- Anti-DXR monoclonal antibodies can prevent doxorubicin-induced damage.
- Apoptosis in the tongue of doxorubicin-treated mice was completely inhibited by the antibody.
Takeaway
This study found that a special antibody can stop mouth damage caused by a cancer drug in mice.
Digital Object Identifier (DOI)
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