Cobalamin in inflammation III — glutathionylcobalamin and methylcobalamin/adenosylcobalamin coenzymes: the sword in the stone? How cobalamin may directly regulate the nitric oxide synthases
2007
How Cobalamin Affects Inflammation and Nitric Oxide Production
publication
Evidence: moderate
Author Information
Author(s): Carmen Wheatley
Primary Institution: Orthomolecular Oncology, Oxford, UK
Hypothesis
Cobalamin regulates inflammation by controlling nitric oxide production through its effects on nitric oxide synthases.
Conclusion
Cobalamin may play a central role in regulating both pro-inflammatory and anti-inflammatory systems by influencing nitric oxide synthases.
Supporting Evidence
- Cobalamin directly controls key inflammatory cytokines like TNFα and interleukin 6.
- Cobalamin modulates immunity through its effects on CD8+ T lymphocytes and natural killer cell activity.
- Glutathionylcobalamin can selectively promote nitric oxide production in the early stages of inflammation.
Takeaway
Cobalamin, a form of vitamin B12, helps control inflammation in the body by managing how nitric oxide is produced.
Digital Object Identifier (DOI)
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