Genome of Human Bocavirus Episome
2011
Human Bocavirus Episome Found in Infected Tissue
Sample size: 22
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Amit Kapoor, Mady Hornig, Aravind Asokan, Brent Williams, Jose A. Henriquez, W. Ian Lipkin
Primary Institution: Columbia University
Hypothesis
Can human bocavirus (HBoV) establish persistent infections in humans?
Conclusion
HBoV DNA can exist as episomes in infected human tissues, suggesting a potential for persistent infection.
Supporting Evidence
- Four out of 22 intestinal biopsy samples tested positive for HBoV DNA.
- One sample contained the episomal form of HBoV3.
- The complete genome sequence of HBoV3-E1 was determined to be 5319 nucleotides long.
Takeaway
This study found that a virus called human bocavirus can stick around in our bodies for a long time, even when we don't feel sick.
Methodology
Intestinal biopsies from 22 children were tested for HBoV DNA using PCR techniques.
Limitations
The study tested a small number of samples, which may not represent the broader population.
Participant Demographics
22 children with gastrointestinal disease.
Digital Object Identifier (DOI)
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