E-selectin Polymorphism and Coronary Artery Disease in Arabs
Author Information
Author(s): Abu-Amero Khaled K, Al-Boudari Olayan M, Mohamed Gamal H, Dzimiri Nduna
Primary Institution: King Faisal Specialist Hospital and Research Centre
Hypothesis
Is the E-selectin S128R polymorphism associated with severe coronary artery disease in Arabs?
Conclusion
The E-selectin S128R polymorphism is associated with severe coronary artery disease in Saudi Arabs, but this association disappears when considering other risk factors.
Supporting Evidence
- The frequency of the mutant 128R allele was higher among CAD patients compared to controls (11% vs. 6%).
- The odds ratio for the risk of CAD associated with the 128R allele was 1.76.
- The study included a total of 793 participants.
Takeaway
This study looked at a gene that might make people more likely to have heart problems. They found that a certain change in the gene was more common in people with heart disease.
Methodology
The study genotyped Saudi Arabs for the E-selectin S128R polymorphism using PCR and restriction enzyme digestion.
Limitations
The association of the polymorphism with CAD was lost in multivariate analysis, indicating potential confounding by other risk factors.
Participant Demographics
The study included 556 CAD patients (396 males, 160 females) and 237 control subjects (105 males, 132 females), with a mean age of 50 years.
Statistical Information
P-Value
0.007
Confidence Interval
95% CI 1.14 – 2.72
Statistical Significance
p = .007
Digital Object Identifier (DOI)
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