Effect of Hepatocyte Growth Factor on Neutrophil Granule Enzyme Release
1993
Hepatocyte Growth Factor Stimulates Neutrophil Degranulation
Sample size: 9
publication
Evidence: moderate
Author Information
Author(s): I. C. Kowanko, A. Ferrante, T. Nakamura
Primary Institution: Women's and Children's Hospital, North Adelaide, Australia; Kyushu University, Fukuoka, Japan
Hypothesis
Does hepatocyte growth factor (HGF) influence neutrophil function?
Conclusion
HGF modulates neutrophil granule exocytosis but does not affect respiratory burst, adherence, or locomotion.
Supporting Evidence
- HGF at 1-10 ng/ml increased lysosomal enzyme release from neutrophils.
- The release of specific granule contents in response to N-formyl-methionyl-leucyl-phenylalanine was increased by HGF.
- HGF did not significantly affect neutrophil respiratory burst, adherence, or locomotion.
Takeaway
HGF helps neutrophils release important enzymes but doesn't change how they move or respond to other signals.
Methodology
Neutrophils were treated with HGF and stimulated to measure enzyme release and other functions.
Limitations
The study did not explore the effects of HGF on all neutrophil functions or in all conditions.
Participant Demographics
Healthy adult volunteers
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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