Study on Bone Marrow Cell Transplantation After Heart Attack
Author Information
Author(s): Dohmann Hans FR, Silva Suzana A, Sousa André LS, Braga Alcione MS, Branco Rodrigo VC, Haddad Andréa F, Oliveira Mônica A, Moreira Rodrigo C, Tuche Fabio AA, Peixoto Cíntia M, Tura Bernardo R, Borojevic Radovan, Ribeiro Jorge P, Nicolau José C, Nóbrega Antonio C, Carvalho Antonio CC
Primary Institution: Departamento de Pesquisa Clínica, Centro de Ensino e Pesquisa do Pró-Cardíaco/PROCEP, Rio de Janeiro, Brasil
Hypothesis
Treated patients will have a significantly higher ejection fraction improvement after 6 months than controls.
Conclusion
The study aims to determine if bone marrow cell transplantation can improve heart function in patients after a heart attack.
Supporting Evidence
- Myocardial infarction is a major cause of mortality worldwide.
- Many survivors of AMI develop heart failure, leading to high morbidity.
- Cell therapy has shown potential benefits in heart repair.
Takeaway
This study is testing if giving patients special cells from their own bone marrow can help their hearts work better after a heart attack.
Methodology
A multicenter, double blind, randomized and placebo controlled trial involving 300 patients with ST elevation AMI.
Potential Biases
Potential bias in patient selection and reporting of outcomes.
Limitations
The study may not account for all variables affecting heart function improvement.
Participant Demographics
Patients aged between 30 and 80 years with ST elevation AMI and left ventricle systolic dysfunction.
Digital Object Identifier (DOI)
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